The two C5 centers are located in city blocks next to ech other across Polk Street. They are in an urban setting in a maritime climate in the San Francisco Civic Center Neighborhood. The buildings that house both centers look onto City Hall and City Hall Park. In view and a block away are the Asian Art Museum, the Main Branch Public Library, the Community Garden, the County Courthouse, the City Coliseum, the Symphony Hall, the Ballet, and the Herbst Theater. Just across town North and East is the San Francisco Bay, and just West across town is the Pacific Ocean.

The Federal Courthouse and office building is North, across the street from the C5 CA State Building Center. The University of California Hastings Law School is nearby.

The County Courthouse is across Redwood Alley and South of the C5 SF City Building Center.